The Quattroflow® QuattroMix Single-Use Mixing System features a Quattroflow Four-Piston Diaphragm Pump used to circulate liquids and solids inside a mixing bag in order to achieve the necessary mix and dilution rates, all within an optimized time frame.

Buffers and Media must be prepared properly to ensure effective biopharmaceutical production. This requires flow-measurement systems that are able to operate with little variance. The SumoFlo® Flow Meter provides extremely high accuracy with a ±1% of mass flow rate reading, while the BioProTT™ FlowSU System and BioProTT™ FlowMeasurement system utilize non-invasive ultrasonic for flow measurement.

As part of the harvesting process, centrifuges are used to separate the proteins of interest from the cell mass while simultaneously maintaining the structural integrity of the protein. Quattroflow® Four-Piston Diaphragm Pumps are ideal for use in this process step.

Microbial fermentation is used in the production of biopharmaceutical products to extract, concentrate and purify the resulting finished product. The SumoFlo® Flow Meter and BioProTT™ FlowMeasurement System can handle changes in mass flow rate, density, volumetric flow rate and temperature with no need of individual calibration and without putting additional shear stress on the pumped fluid.

Realizing the importance of using pumping equipment that can overcome the challenges in chromatography applications, Quattroflow® offers its Four-Piston Diaphragm Pump technology.

Chromatography is used to separate, identify and purify the components in a biopharmaceutical-production process. This requires gentle, shear-sensitive pumping and flow-measurement technology.

In this realm, the SumoFlo® is not affected by changes in mass flow rate, density, volumetric flow rate and temperature, while the BioProTT™ FlowSU System and BioProTT™ FlowMeasurement System offer innovative single-use ultrasonic flow measurement and non-invasive ultrasonic flow measurement solution without putting unwanted shear stress on the fluid.

Inline buffer dilution is a method for on demand buffer preparation at the location of operation. It is used in all kinds of biopharma processes such as chromatography and in various filtration steps.

Quattroflow pumps are ideal in this sensitive process step thanks to their special design and the associated advantages.

The prodictuon of today's biologics requires large volumes of downstream dilute buffers, all of which can tolerate no variance in flow rate or volume. By using the SumoFlo®, BioProTT™ FlowSU System or BioProTT™ Flow Measurement System the producers of biologics can help ensure that their flow-measurement activities are as accurate and reliable as necessary.

Tangential Flow Filtration (TFF), also known as cross-flow filtration, is a rapid and efficient method to separate and purify biomolecules. Quattroflow® Four-Piston Diaphragm Pumps can be an indispensable piece in this sensitive process step thanks to their fluid-sensitive operating principle.

Tangential Flow Filtration (TFF) is used to separate cells or proteins through the removal of unwanted components in a fluid stream. Quattroflow® Four-Piston Diaphragm Pumps can excel in this sensitive and precise process thanks to their gentle fluid-handling operation.

Tangential Flow Filtration (TFF) is a filtering and separation process that requires accurate flow control as the biologic material is gently pushed across a membrane. The SumoFlo® Single-Use Coriolis Flow Meter offers superior flow-measurement accuracy while reducing the risk of measurement error, while the BioProTT™ FlowSU System and BioProTT™ FlowMeasurement System are both able to help produce shear-free fluid transfer.

In Tangential Flow Filtration (TFF), a biologic fluid flows across a filter membrane in order to remove any impurities from the fluid. Flow meters such as the SumoFlo®, BioProTT™ FlowSU System and BioProTT™ FlowMeasurement System can offer superior non-invasive flow-measurement performance while helping to produce accurate, shear-free flow rates.

Virus Filtration (nanofiltration) removes viruses by size exclusion, a process that requires precise, accurate fluid volumes with no room for deviation. Quattroflow® Four-Piston Diaphragm Pumps possess the accuracy and low-pulsation oepration to satisfy the stricts demands of this critical application.

Removing viruses from fluids via a Virus Filtration process is a critifcal step in many bioprocessing applications. Because this stage requires consistant, accurate and gentle fluid handling, relibale flow control is a must, making the SumoFlo®, BioProTT™ FlowSU System and BioProTT™ FlowMeasurement System first-choice flow-measurement technologies in this realm.

Many bioprocessing applications require the transfer of large volumes of fluids into storage or holding containers. Quattroflow® Four-Piston Diaphragm Pumps are able to cover the high flow rates that are required for these fluid-transfer activities.

Today's bioprocessing manufacturers use large volumes of fluids that must be transferred into and out of bulk-storage containers. This rquires the strict monotoiring of flow rates and volumes, the accuracy of which can be optimized with the aid of the SumoFlo®, BioProTT™ FlowSU System and BioProTT™ Flow Measurement Systems, which possess the capability to deliver highly accurate non-invasive flow measurement and control.

Tangential Flow Filtration (TFF), also known as cross-flow filtration, is a rapid and efficient method to separate and purify biomolecules. Quattroflow® Four-Piston Diaphragm Pumps can be an indispensable piece in this sensitive process step thanks to their fluid-sensitive operating principle.

The process of inline buffer dilution is used to blend or dilute multiple buffers during chromatography activities. The goal is to fine-tune the concentration of the buffer so that it meets the needs of the production process.

Inline buffer dilution demands a pumping technology that is gentle and able to maintain consistent and precise flow rates. All qualities of the Quattroflow® Four-Piston Diaphragm Pumps.

Why are Quattroflow pumps the world's leading technology in chromatography applications? Click below to find the answers and learn more.